Preferred Label : Adeno-associated Virus Encoding Anti-CD19/Anti-CD3 Bispecific Diabody VNX-101;
NCIt synonyms : AAV Encoding Anti-CD19/Anti-CD3 Bispecific Diabody VNX-101; AAV Encoding Anti-CD19/Anti-CD3 Bispecific T-cell Engager VNX-101; AAV.CD3/CD19; AAV Encoding Anti-CD19/Anti-CD3 Bispecific Diabody GP101 VNX-101;
NCIt definition : An off-the-shelf preparation of adeno-associated virus (AAV) encoding the anti-CD19/anti-CD3
bispecific diabody GP101, with potential immunostimulating and antineoplastic activities.
Upon administration, AAV encoding anti-CD19/anti-CD3 bispecific diabody VNX-101 induces
the secretion of GP101 by hepatocytes and other cells into the bloodstream. GP101
binds to both the CD3 antigen on T-cells and the CD19 antigen expressed on tumor cells.
This results in the cross-linking of T-cells and tumor cells, and induces a cytotoxic
T-lymphocyte (CTL) response against CD19-expressing tumor cells. CD19 antigen is a
B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.;
Molecule name : VNX 101; VNX-101;
Origin ID : C213748;
concept_is_in_subset
- has_target
