Preferred Label : Anti-uPARAP ADC ADCE-D01;
NCIt synonyms : uPARAP Targeting ADC ADCE-D01; Anti-uPARAP/P1021 ADC ADCE-D01; Antibody-drug Conjugate ADCE-D01; ADC ADCE-D01;
NCIt definition : An antibody-drug conjugate (ADC) composed of AB-004, a humanized monoclonal antibody
directed against urokinase plasminogen activator receptor-associated protein (uPARAP;
endocytic receptor 180; Endo180; C-type mannose receptor 2) conjugated, via a protease-cleavable
tetra-peptide linker, to the topoisomerase-1 inhibitor (TOP1i) P1021, with potential
antineoplastic activity. Upon administration of anti-uPARAP ADC ADCE-D01, AB-004 targets
and binds to uPARAP-expressing tumor cells. Upon binding, internalization and linker
cleavage, P1021 is released, and inhibits DNA topoisomerase-1 activity, thereby inhibiting
DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This
inhibits the proliferation of uPARAP-expressing tumor cells. uPARAP, a recycling endocytic
receptor involved in collagen homeostasis and turnover, is overexpressed on various
tumor cell types while its expression is limited in healthy tissues.;
Molecule name : ADCE-D01; ADCE D01;
Origin ID : C213656;
concept_is_in_subset
- has_target
