Preferred Label : Idroxioleate Sodium;
NCIt synonyms : 2-OHOA Sodium;
NCIt definition : The sodium salt form of idroxioleic acid, an orally bioavailable, synthetic analog
of the fatty acid oleic acid, with potential antitumor activity. Upon administration,idroxioleic
acid activates sphingomyelin synthase (SMS), thereby increasing the concentration
of sphingomyelin (SM) and diacylglycerol (DAG) in the tumor cell membrane and decreasing
membrane levels of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). This
restores the normal, healthy levels and ratios of membrane lipids. By restoring normal
membrane lipid structure and composition, this agent inhibits membrane-protein associated
signaling and the aberrant activity of signaling pathways in certain tumor cells,
including the Ras/MAPK and PI3K/AKt pathways. This inhibits tumor cell proliferation,
induces tumor cell differentiation, and eventually can cause cell death.;
UNII : Q0O588YY4Z;
CAS number : 1229114-68-4;
Molecule name : LAM 561; LAM-561;
Origin ID : C213360;
concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
