NCIt definition : An orally bioavailable, synthetic analog of the fatty acid oleic acid, with potential
antitumor activity. Upon administration,idroxioleic acid activates sphingomyelin synthase
(SMS), thereby increasing the concentration of sphingomyelin (SM) and diacylglycerol
(DAG) in the tumor cell membrane and decreasing membrane levels of phosphatidylethanolamine
(PE) and phosphatidylcholine (PC). This restores the normal, healthy levels and ratios
of membrane lipids. By restoring normal membrane lipid structure and composition,
this agent inhibits membrane-protein associated signaling and the aberrant activity
of signaling pathways in certain tumor cells, including the Ras/MAPK and PI3K/AKt
pathways. This inhibits tumor cell proliferation, induces tumor cell differentiation,
and eventually can cause cell death.;
UNII : OSV3KVO1BT;
CAS number : 56472-29-8;
Drug name : Minerval;
Molecule name : 2-OHOA; SML-0256; NFX88; LAM 561; LAM-561;
Currated CISMeF NLP mapping