Preferred Label : Human Adenovirus Type 5 Encoding HPV-16 E6/E7 Vaccine IBRX-042;
NCIt synonyms : hAd5-encoding HPV16 E6/E7 Vaccine IBRX-042; hAd5 Encoding HPV16 E6/E7 Vaccine IBRX-042; hAd5-HPV E6.ETSD-IRES-E7.ETSD Vaccine IBRX-042;
NCIt definition : A cancer vaccine composed of an adenovirus type 5 (Ad5) vector that encodes for the
viral oncoproteins E6 and E7 derived from human papillomavirus serotype 16 (HPV-16;
HPV16), with potential immunomodulating and antineoplastic activities. Upon administration,
hAd5 encoding HPV-16 E6/E7 vaccine IBRX-042 induces expression of the HPV-16 E6/E7
proteins, which stimulates the host immune system to mount a cytotoxic T-lymphocyte
(CTL)-mediated response against tumor cells expressing HPV-16 E6 and E7. Oncoproteins
E6 and E7 play a key role in the development of various malignancies.;
Molecule name : IBRX 042; IBRX-042;
Origin ID : C213159;
concept_is_in_subset
- has_target
