Preferred Label : Anti-integrin AlphaV/Beta8 Monoclonal Antibody CRB-601;
NCIt synonyms : Anti-integrin aVb8 Monoclonal Antibody CRB-601;
NCIt definition : A humanized immunoglobulin G4 (IgG4) monoclonal antibody directed against integrin
alphaV/beta8 (aVb8), with potential antineoplastic activity. Upon administration,
anti-integrin aVb8 monoclonal antibody CRB-601 targets and binds to integrin aVb8.
This prevents the binding of integrin aVb8 to latent human transforming growth factor
(TGF)-beta (L-TGFb) and inhibits the activation of L-TGFb complexes, thereby preventing
TGFb-mediated signaling. This abrogates TGFb-mediated immunosuppression, enhances
anti-tumor immunity in the tumor microenvironment (TME) and promotes a cytotoxic T-lymphocyte
(CTL)-mediated immune response against tumor cells leading to tumor cell death. This
may lead to a reduction in TGFb-dependent proliferation of cancer cells. Integrin
aVb8 plays a key role in tumor initiation, growth, and progression through TGF-b activation.
It is expressed in a variety of tumor cell types and is associated with poor prognosis.;
Molecule name : CRB-601; CRB 601;
Origin ID : C212145;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
