Preferred Label : Allogeneic Anti-CD19 CAR Double-negative T Cells RJMty19;
NCIt synonyms : Bi-negative T-cells RJMty19; Allo-DNT Cells RJMty19; Allogeneic Anti-CD19 CAR DNT Cells RJMty19; Lentiviral vector-transduced Anti-CD19-CAR DNT Cells RJMty19; Allogeneic DNTs RJMty19; Allogeneic DNT Cells RJMty19; CD19-CAR-DNT Cells RJMty19; Allogeneic Anti-CD19 CAR-engineered Double Negative T Cells RJMty19;
NCIt definition : An off-the-shelf (OTS) cell preparation composed of healthy, donor-derived CD4 and
CD8 double-negative T-lymphocytes (DNTs) that are transduced with a lentiviral vector
expressing a humanized chimeric antigen receptor (CAR) targeting the human tumor-associated
antigen (TAA) CD19, with potential immunomodulating and antineoplastic activities.
Upon administration, the allogeneic anti-CD19 CAR DNTs RJMty19 specifically targets
and binds to tumor cells expressing CD19. This induces selective toxicity in tumor
cells that express CD19. CD19 is a B-cell-specific cell surface antigen overexpressed
in B-cell lineage malignancies. The DNTs contain a high proportion of stem cell-like
memory T cells (Tscm).;
Molecule name : RJMty 19; RJMty-19;
Origin ID : C212073;
concept_is_in_subset
- has_target
