Preferred Label : Anti-GPRC5D/Anti-CD19 CAR T Cells;
NCIt synonyms : Anti-CD19/Anti-GPRC5D CAR T Cells; Anti-GPRC5D/CD19 CAR T Cells; Anti-GPRC5D-CD19-CAR-T Cells; GPRC5D-CD19 CAR T Cells;
NCIt definition : A preparation of T-lymphocytes engineered to express chimeric antigen receptor(s)
(CARs) targeting the human tumor-associated antigens (TAAs) G-protein coupled receptor
family C group 5 member D (GPRC5D) and CD19, with potential immunostimulating and
antineoplastic activities. Upon administration, anti-GPRC5D/anti-CD19 CAR T cells
specifically and simultaneously target and bind to tumor cells expressing GPRC5D and/or
CD19. This induces selective toxicity in tumor cells that express GPRC5D and/or CD19.
GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally
expressed in normal, healthy cells. It plays a key role in tumor cell proliferation.
CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage malignancies.;
Origin ID : C212050;
concept_is_in_subset
- has_target
