Preferred Label : Anti-CLDN6/CD3 Bispecific Antibody CTIM-76;
NCIt synonyms : CLDN6 x CD3 Bispecific Antibody CTIM-76; CLDN6-directed TCE CTIM-76; Anti-CLDN6/CD3 T-cell Engaging Bispecific Antibody CTIM-76; Anti-Claudin-6/CD3 Bispecific Antibody CTIM-76; CLDN6 x CD3 T-cell Engaging Bispecific Antibody CTIM-76; CLDN6 T-cell Engager Antibody CTIM-76; Anti-CD3/CLDN6 Bispecific Antibody CTIM-76; Anti-CLDN6/Anti-CD3 Bispecific Antibody CTIM-76; Claudin-6-directed Bispecific Antibody CTIM-76;
NCIt definition : An Fc-silenced humanized immunoglobulin G1 (IgG1) bispecific antibody targeting both
the tumor-associated antigen (TAA) claudin 6 (CLDN6; CLDN-6) and the T-cell surface
antigen CD3, with potential immunostimulating and antineoplastic activities. Upon
intravenous administration, anti-CLDN6/CD3 bispecific antibody CTIM-76 targets and
binds to both CLDN6 expressed on tumor cells and CD3 expressed on T-cells. This activates
and redirects cytotoxic T-lymphocytes (CTLs) to CLDN6-expressing tumor cells, which
leads to enhanced CTL-mediated killing of CLDN6-expressing tumor cells. CLDN6, a tight-junction
protein and embryonic antigen, is overexpressed on a variety of tumor cells but is
not or minimally expressed on normal, healthy adult cells.;
Molecule name : CTIM-76; CTIM 76;
Origin ID : C211941;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
