NOVA Family - CISMeF

Preferred Label : NOVA Family;

NCIt definition : Expressed in brain (neurons or astrocytes), NOVA Family Genes encode NOVA Family nuclear proteins (NOVA1, NOVA2), autoantigens in POMA recognized by IgG ANNA-2 that contain 3 KH domains and may regulate RNA splicing in neurons and astrocytes. NOVA proteins form structural complexes with other proteins. Found as one or multiple copies of a conserved 70-aa motif in diverse nucleic acid binding, and other, proteins, the KH domain binds RNA; each motif appears necessary for binding. (NCI);

Details

Origin ID

C21181;

UMLS CUI

C1334892;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- NOVA Family Gene [NCIt concept]
gene_product_has_biochemical_function
- RNA Binding Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- RNA Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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