Preferred Label : Anti-B7-H4/TOP1i Antibody-drug Conjugate GSK5733584;
NCIt synonyms : Anti-B7-H4/Topoisomerase I Inhibitor ADC GSK5733584; Anti-B7-H4 Antibody-drug Conjugate GSK5733584; Anti-B7-H4 ADC GSK5733584; Anti-B7-H4/TOP1i ADC GSK5733584;
NCIt definition : An antibody-drug conjugate (ADC) composed of a humanized immunoglobulin G1 (IgG1)
monoclonal antibody directed against B7-H4 (V-set domain-containing T-cell activation
inhibitor 1; VTCN1; B7x; B7S1) linked, via a protease-cleavable linker, to a topoisomerase-1
inhibitor (TOP1i; TOP-Ii), with potential antineoplastic activity. Upon administration
of anti-B7-H4/ TOP1i ADC GSK5733584, the anti-B7-H4 monoclonal antibody moiety targets
and binds to B7-H4 expressed on tumor cells. Upon binding and internalization, the
TOP1i moiety binds to TOP1 and stabilizes cleaved DNA-TOP1 complexes. This prevents
DNA re-ligation, induces irreversible DNA strand breaks, prevents DNA repair, and
leads to cycle arrest and apoptosis specifically in tumor cells expressing B7-H4.
B7-H4, a member of the B7 family of immune modulators, is upregulated in a variety
of tumor cell types and tumor-associated macrophages. It negatively regulates T-cell
immune responses.;
Molecule name : HS-20089; GSK-5733584; HS 20089; GSK 5733584;
Origin ID : C210991;
concept_is_in_subset
- has_target
