Preferred Label : Lipid Nanoparticle Encapsulating Beta-catenin siRNA ALN-BCAT;
NCIt synonyms : Beta-catenin-targeting RNAi Therapeutic ALN-BCAT; Beta-catenin-targeting RNA Interference Therapeutic ALN-BCAT; LNP Encapsulating Beta-catenin siRNA ALN-BCAT;
NCIt definition : A formulation consisting of lipid nanoparticle (LNP)-encapsulated small interfering
ribonucleic acid (siRNA) targeting beta-catenin, with potential antineoplastic activity.
Upon administration of LNP encapsulating beta-catenin siRNA ALN-BCAT, the LNP formulation
delivers the siRNA particles to the tumor cells where the beta-catenin siRNA targets
and binds to beta-catenin mRNA. This results in the inhibition of the translation
and expression of beta-catenin. This disrupts beta-catenin-dependent oncogenic signaling
and prevents the transcription of Wnt target genes that regulate the proliferation,
migration, invasion, and the metastatic potential of tumor cells, as well as genes
regulating the immunosuppression of the tumor microenvironment (TME). Dysregulation
of the Wnt/beta-catenin signaling pathway is found in a variety of tumors and drives
oncogenesis.;
Molecule name : ALN BCAT; ALN-BCAT;
Origin ID : C210897;
concept_is_in_subset
- has_target
