Preferred Label : MDM2 Inhibitor SA53-OS;
NCIt definition : An orally bioavailable inhibitor of murine double minute 2 (MDM2), with potential
antineoplastic activity. Upon oral administration, MDM2 inhibitor A53-OS targets and
binds to the MDM2 protein and prevents its binding to the transcriptional activation
domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction,
the transcriptional activity of p53 is restored. This leads to p53-mediated induction
of tumor cell apoptosis. MDM2, a zinc finger protein and a negative regulator of the
p53 pathway, is overexpressed in cancer cells; it plays a key role in cancer cell
proliferation and survival.;
Molecule name : SA53 OS; SA53-OS;
Origin ID : C210636;
concept_is_in_subset
- has_target
