Preferred Label : DNA Polymerase Theta Inhibitor RP-3467;
NCIt synonyms : Pol Theta Inhibitor RP-3467;
NCIt definition : An orally bioavailable inhibitor of DNA polymerase (pol) theta, with potential chemosensitizing
and antineoplastic activities. Upon oral administration, pol theta inhibitor RP-3467
specifically targets, binds to and inhibits the activity of pol theta. This prevents
pol theta-mediated repair of double-stranded DNA breaks via the microhomology-mediated
end joining (MMEJ) process. This causes apoptosis and inhibits proliferation in cancer
cells. RP-3467 may have a synergistic effect if administered in combination with agents
that cause DNA damage. Pol theta plays a key role in DNA synthesis and repair that
is highly expressed in cancer cells while nearly absent in most healthy tissues. It
plays a key role in cancer cell survival.;
Molecule name : RP 3467; RP-3467;
Origin ID : C210428;
concept_is_in_subset
- has_target
