DNA Polymerase Theta

Preferred Label : DNA Polymerase Theta;

NCIt synonyms : POLQ; EC 2.7.7.7;

NCIt definition : DNA polymerase theta (2590 aa, 290 kDa) is encoded by the human POLQ gene. This protein is involved in microhomology-mediated end-joining and low-fidelity DNA synthesis.;

Details

Origin ID

C131803;

UMLS CUI

C1568393;

Automatic exact mappings (from CISMeF team)
- DNA polymerase theta [HGNC gene]
- Polymerase, dna, kappa [OMIM gene]
- Polymerase, dna, theta [OMIM gene]
Currated CISMeF NLP mapping
- DNA Polymerase theta [MeSH Descriptor]
- DNA polymerase theta [MeSH concept]
OMIM relation
- Polymerase, dna, theta [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- POLQ protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- POLQ Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Polymerase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- DNA Repair [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Polymerization [NCIt concept]
is_target
- DNA Polymerase Theta Inhibitor ART6043 [NCIt concept]
- DNA Polymerase Theta Inhibitor GSK4524101 [NCIt concept]
- Pol Theta Inhibitor ART4215 [NCIt concept]

Keyword's position in hierarchy(ies) :

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