Preferred Label : Anti-PD-1/IL-2 Fusion Protein TEV-56278;
NCIt synonyms : PD-1-targeted IL-2 TEV-56278; Anti-PD1-IL2 Fusion Protein TEV-56278;
NCIt definition : A recombinant fusion protein composed of an antibody directed against the human negative
immunoregulatory checkpoint receptor programmed cell death protein 1 (PD-1; PDCD1;
CD279) fused to the cytokine interleukin-2 (IL-2), with potential immunostimulating
and antineoplastic activities. Upon administration of anti-PD-1/IL-2 fusion protein
TEV-56278, the antibody moiety targets and binds to PD-1 expressed on PD-1-expressing
T-cells in the tumor microenvironment (TME). The IL-2 moiety stimulates a local immune
response and activates natural killer (NK) cells and cytotoxic T-cells, which may
enhance the activity of neoantigen specific T-cells and potentiate T-cell-mediated
immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin
superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively
regulates T-cell activation and effector function when activated by its ligands, programmed
cell death-1 ligand 1 (PD-L1; B7-H1; CD274) and 2 (PD-L2); it plays an important role
in tumor evasion from host immunity.;
Molecule name : TEV 56278; TEV-56278;
Origin ID : C210121;
concept_is_in_subset
- has_target
