Preferred Label : Alpha-clash Anti-IL-2 Antibody Fusion Protein LAT010;
NCIt synonyms : Antibody Fusion Protein LAT010; Immunocytokine LAT010; a-Clash IL-2 Antibody Fusion Protein LAT010; IL-2-based Immunocytokine LAT010;
NCIt definition : An antibody fusion protein and interleukin-2 (IL-2) immunocytokine, with potential
antineoplastic activity. Upon administration of the alpha-clash anti-IL-2 antibody
fusion protein LAT010, the IL-2 moiety targets and binds to the intermediate-affinity
IL-2 receptor beta,gamma (IL-2Rbg), thereby selectivity activating CD8 T-cells and
natural killer (NK) cells against tumor cells. The alpha-clash anti-IL-2 antibody
moiety of LAT010 prevents LAT010 from activating the high-affinity IL2Ralpha,beta,gamma
receptor complex which may prevent severe IL-2-mediated systemic toxic effects.;
Molecule name : LAT-010; LAT 010;
Origin ID : C209754;
concept_is_in_subset
- has_target
