Preferred Label : Pan-KRAS Inhibitor PF-07934040;
NCIt synonyms : Pan-KRAS Mutant Inhibitor PF-07934040; KRAS Inhibitor PF-07934040;
NCIt definition : An orally bioavailable inhibitor of KRAS mutations, with potential antineoplastic
activity. Upon oral administration, pan-KRAS inhibitor PF-07934040 targets, binds
to and inhibits various forms of KRAS mutations, thereby inhibiting KRAS-dependent
signaling. This inhibits the proliferation of and induces apoptosis in tumor cells
in which KRAS is mutated. KRAS plays an important role in cell signaling, division
and differentiation. Mutations of KRAS may induce constitutive signal transduction
leading to tumor cell growth, proliferation, invasion, and metastasis.;
Molecule name : PF 4040; PF-07934040; PF 07934040; PF-4040;
Origin ID : C209714;
concept_is_in_subset
- has_target
