" /> G1/S-Specific Cyclin-E2 - CISMeF





Preferred Label : G1/S-Specific Cyclin-E2;

NCIt synonyms : CCNE2; CCNE2 Protein; G1/S-Specific Cyclin E2; Cyclin E2; Cyclin-E2;

NCIt definition : G1/S-specific cyclin-E2 (404 aa, 47 kDa) is encoded by the human CCNE2 gene. This protein plays a role in cell cycle checkpoint regulation between the G1 and S phases.;

NCIt note : Cyclin E1, a protein encoded by the CCNE1 gene, forms a complex with and functions as a regulatory subunit of CDK2, whose activity is essential for the control of the cell cycle at the G1/S (start) transition. Cyclin E1 accumulates at the G1-S phase boundary and phosphorylation by CDK2 triggers its release from CDK2 and degradation. Overexpression of this gene is observed in many tumors, which results in chromosome instability and may contribute to tumorigenesis. Cyclin E1 is associated with and involved in the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two isoforms, E1L and E1S, are produced by alternative splicing and E1S cannot complex with CDK2. Cyclin E1 is highly expressed in testis and placenta with low levels in bronchial epithelial cells.;

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18/05/2024


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