Methylglutaconyl-CoA Hydratase, Mitochondrial

Preferred Label : Methylglutaconyl-CoA Hydratase, Mitochondrial;

NCIt synonyms : Enoyl-Coenzyme A Hydratase; AU RNA-Binding Protein; AU RNA-Binding Protein/enoyl-Coenzyme A Hydratase; AU-Specific RNA Binding Protein; MGA Type I; AUH; 3-Methylglutaconyl-CoA Hydratase; AU-RNA Binding Protein; AU-Binding Protein/Enoyl-CoA Hydratase; EC 4.2.1.18; AU-Specific RNA-Binding Protein/Enoyl-CoA Hydratase; AU RNA Binding Protein;

NCIt definition : Methylglutaconyl-CoA hydratase, mitochondrial (339 aa, 36 kDa) is encoded by the human AUH gene. This protein is involved in amino acid catabolism.;

NCIt note : Methylglutaconyl-CoA hydratase, mitochondrial binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation.;

Details

Origin ID

C20950;

UMLS CUI

C0295398;

OMIM relation
- Au-specific rna-binding protein [OMIM gene]
See also inter- (CISMeF)
- 3-methylglutaconic aciduria, type I [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- AUH protein, human [MeSH concept]
- AUH protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- AUH Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Lyase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Mitochondrial Matrix [NCIt concept]
gene_product_has_biochemical_function
- RNA Binding Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Valine, Leucine and Isoleucine Degradation Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- 3-Methylglutaconic Aciduria Type 1 [NCIt concept]
gene_product_plays_role_in_biological_process
- Intermediary Metabolic Process [NCIt concept]
- RNA Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients