Tetraspanin-8 - CISMeF

Preferred Label : Tetraspanin-8;

NCIt synonyms : Tetraspanin 8; TSPAN8; Transmembrane 4 Superfamily Member 3; Tumor-Associated Antigen CO-029; Tspan-8;

NCIt definition : Tetraspanin-8 (237 aa, 26 kDa) is encoded by the human TSPAN8 gene. This protein is involved in mTORC2 activation, integrin signaling and co-localization of proteases and substrates in tetraspanin-enriched microdomains.;

Details

Origin ID

C209370;

OMIM relation
- Tetraspanin 8 [OMIM gene]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Signaling Pathway Gene [NCIt concept]
- TSPAN8 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Scaffolding Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Negative Regulation of Apoptosis [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-TSPAN8/Anti-CD3 Bispecific Antibody ASP2074 [NCIt concept]

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