Platelet Basic Protein

Preferred Label : Platelet Basic Protein;

NCIt synonyms : PPBP; PBP; CXC Chemokine Ligand 7; C-X-C Motif Chemokine 7; LDGF; Small Inducible Cytokine Subfamily B, Member 7; Leukocyte-Derived Growth Factor; MDGF; Macrophage-Derived Growth Factor; Thrombocidin 1; Small-Inducible Cytokine B7; Thrombocidin 2; Pro-Platelet Basic Protein;

NCIt definition : Platelet basic protein (128 aa, 14 kDa) is encoded by the human PPBP gene. This protein is involved in platelet activation, chemotaxis, cytokine receptor binding and anti-bacterial activity.;

NCIt note : Platelet basic protein can be cleaved into the following 10 active peptides: connective tissue-activating peptide III (CTAP-III; LA-PF4; low-affinity platelet factor IV); TC-2; connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); beta-thromboglobulin (Beta-TG); neutrophil-activating peptide 2(74) (NAP-2(74)); neutrophil-activating peptide 2(73) (NAP-2(73)); neutrophil-activating peptide 2 (NAP-2); TC-1; neutrophil-activating peptide 2(66) (NAP-2(66)); neutrophil-activating peptide 2(63) (NAP-2(63)). (UniProt);

Details

Origin ID

C20810;

UMLS CUI

C1622669;

OMIM relation
- Pro-platelet basic protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- platelet basic protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CXC Cytokine Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
- PPBP Gene [NCIt concept]
gene_product_has_associated_anatomy
- Alpha Granule [NCIt concept]
- Central Nervous System [NCIt concept]
- Epithelial Cell [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell-Matrix Adhesion Process [NCIt concept]
- Chemotactic Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Glycolysis [NCIt concept]
- Immune Response Process [NCIt concept]
- Immunoregulation [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukocyte Trafficking [NCIt concept]
- Maturation [NCIt concept]
- Mitosis [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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