Preferred Label : PTTC Topical Ointment ACU-D1;
NCIt synonyms : Pentaerythritol Tetrakis (3-(3,5-Di-tert-butyl-4-hydroxyphenyl) Propionate) Topical
Ointment ACU-D1; PTTC-based Topical Ointment ACU-D1; Proteasome Inhibitor Ointment ACU-D1;
NCIt definition : A topical ointment formulation containing pentaerythritol tetrakis (3-(3,5-di-tert-butyl-4-hydroxyphenyl)
propionate) (PTTC), an inhibitor of the 26S proteasome, with potential antiangiogenic
and antineoplastic activities. Upon topical administration of the PTTC topical ointment
ACU-D1, PTTC inhibits the activity of the 26S proteasome, blocking the targeted proteolysis
normally performed by the proteasome and resulting in an accumulation of unwanted
or misfolded proteins. This disrupts various cell signaling pathways and may lead
to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Proteasomes are large
protease complexes that degrade unneeded or damaged proteins that have been ubiquitinated.;
Molecule name : ACU-D1; ACU D1;
Origin ID : C208078;
concept_is_in_subset
- has_target
