Sodium- and Chloride-Dependent GABA Transporter 1

Preferred Label : Sodium- and Chloride-Dependent GABA Transporter 1;

NCIt synonyms : SLC6A1; GAT-1; Solute Carrier Family 6 Member 1;

NCIt definition : Sodium- and chloride-dependent GABA transporter 1 (599 aa, 67 kDa) is encoded by the human SLC6A1 gene. This protein is involved in membrane potential-dependent transport of gamma-aminobutyric acid (GABA).;

NCIt note : Amino acid resorption by sodium-dependent neutral amino acid transporter B(0)AT1 is dependent on the coexpression of either collectrin (CLTRN; TMEM27) in the kidneys or angiotensin-converting enzyme 2 (ACE2) in the intestines. (UniProt);

Details

Origin ID

C207964;

OMIM relation
- Solute carrier family 6 (neurotransmitter transporter, gaba), member 1 [OMIM gene]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- SLC6A1 Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Chemical Synapse [NCIt concept]
- Plasma Membrane [NCIt concept]
- Postsynaptic Membrane [NCIt concept]
- Presynaptic Knob [NCIt concept]
gene_product_has_biochemical_function
- Amino Acid Transporter [NCIt concept]
- Solute Carrier Family [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ion Transport Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Neuronal Transmission [NCIt concept]
- Transmembrane Transport [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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