Preferred Label : Anti-TROP-2 Antibody-drug Conjugate PBI-410;
NCIt synonyms : Anti-TROP-2/TOP1i ADC PBI-410; Anti-TROP-2 ADC PBI-410;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody targeting the tumor-associated
antigen (TAA) trophoblast cell surface protein 2 (trophoblast antigen 2; tumor-associated
calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1) site-specifically
conjugated to a camptothecin analog via a cleavable linker, with potential antineoplastic
activity. Upon administration of the anti-TROP-2 ADC PBI-410, the anti-TROP-2 antibody
targets and binds to TROP-2 expressed on tumor cells. Upon binding and internalization,
the camptothecin analog is released, and inhibits DNA topoisomerase-1 activity, thereby
inhibiting DNA replication and resulting in cell cycle arrest and tumor cell apoptosis.
This inhibits the proliferation of TROP-2-expressing tumor cells. TROP-2 is a transmembrane
protein overexpressed in various tumors. Its expression is associated with enhanced
tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.;
Molecule name : PBI 410; BHV-1510; PBI-410; GQ-1010; GQ 1010; BHV 1510;
Origin ID : C207910;
concept_is_in_subset
- has_target
