Preferred Label : Anti-LILRB4 Monoclonal Antibody BND-35;
NCIt synonyms : ILT3 Antagonist Antibody BND-35; Anti-ILT3 Monoclonal Antibody BND-35;
NCIt definition : A humanized immunoglobulin G4 (IgG4) monoclonal antibody directed against the myeloid-enriched
immune inhibitory receptor leukocyte immunoglobulin-like receptor B member 4 (LILRB4;
ILT3; ILT-3), with potential immune checkpoint inhibitory and antineoplastic activities.
Upon administration, anti-LILRB4 monoclonal antibody BND-35 targets, binds to and
blocks LILRB4, thereby preventing the interaction with its ligands, such as fibronectin,
in the tumor microenvironment (TME). This prevents the activation of LILRB4-mediated
downstream signaling pathways. This may abrogate LILRB4-mediated promotion of myeloid
cell immunosuppression and inhibition of antitumor immunity. This may restore immune
function by activating dendritic cells (DCs) and T-cells, and may promote T-cell-mediated
immune responses against tumor cells. LILRB4, an inhibitory immune receptor highly
expressed on tumor-associated myeloid cells, primarily tolerogenic DCs, myeloid-derived
suppressor cells (MDSCs) and M2 macrophages, functions as an immune checkpoint that
negatively regulates DC- and T-cell activation. It is upregulated in several tumor
types and plays an important role in tumor infiltration, immunosuppression and immune
tolerance.;
Molecule name : BND 35; BND-35;
Origin ID : C207814;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
