Preferred Label : Anti-TROP2 Antibody-drug Conjugate OBI-992;
NCIt synonyms : Anti-TROP2/TOP1i ADC OBI-992; Anti-TROP2 ADC OBI-992; Anti-TROP2 ADC BSI-992;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the tumor-associated antigen (TAA) trophoblast cell surface protein 2 (trophoblast
antigen 2; calcium signal transducer 2; TROP2; TROP-2; TACSTD2; GA733-1; M1S1), conjugated
to a topoisomerase-1 inhibitor (TOP1i; TOP-Ii) via a hydrophilic, enzyme-cleavable
linker, with potential antineoplastic activity. Upon administration of anti-TROP2
ADC OBI-992, the anti-TROP2 antibody moiety targets and binds to TROP2 expressed on
tumor cells. Upon binding, internalization and linker cleavage, the TOP1i moiety is
released, binds to TOP1 and inhibits DNA topoisomerase I activity, thereby inhibiting
DNA replication and resulting in cell cycle arrest and tumor cell apoptosis. This
inhibits the proliferation of TROP2-expressing tumor cells. TROP2 is a transmembrane
protein overexpressed in various tumors. Its expression is associated with enhanced
tumor aggressiveness, metastasis, drug resistance and increased tumor cell survival.;
Molecule name : BSI-992; OBI 992; BSI 992; OBI-992;
Origin ID : C207806;
concept_is_in_subset
- has_target
