Preferred Label : Kininogen Family Gene;
NCIt definition : Encoding Kininogen proteins, Kininogen Family Genes belong to the Cystatin Superfamily,
a single evolutionary superfamily of three inhibitory subfamilies that encode proteins
with likely protective function and structural similarities that include cystatin-like
sequences: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens.
Many members are active cysteine protease inhibitors; others have lost or never acquired
inhibitory activity. Kininogens contain 3 cystatin-like domains, each with 2 disulfide
bonds. Type 2 Cystatins contain multiple cystatin-like domains and have 2 intrachain
disulfide bonds. Type 1 Cystatins contain multiple cystatin-like domains and lack
disulfide bridges. (NCI);
Origin ID : C20730;
UMLS CUI : C1334326;
Semantic type(s)
- gene_found_in_organism
- gene_plays_role_in_process
