Preferred Label : STAT3 Dual Phosphorylation Site Inhibitor YY201;
NCIt synonyms : STAT3 Inhibitor YY201;
NCIt definition : An orally bioavailable inhibitor of signal transducer and activator of transcription
3 (STAT3), with potential antineoplastic activity. Upon oral administration, STAT3
dual phosphorylation site inhibitor YY201 targets, binds to and inhibits Tyr705 and
Ser727 double-site phosphorylation of STAT3, thereby inhibiting the function of STAT3.
This prevents STAT3 binding to responsive gene promoters, STAT3-mediated signaling
and the expression of STAT3 target genes. This inhibits the proliferation of STAT3-overexpressing
tumor cells. STAT3 regulates the transcription of genes involved in several cellular
functions. STAT3 is constitutively activated in a variety of human cancers and plays
a key role in neoplastic transformation, uncontrolled tumor cell proliferation, resistance
to apoptosis, metastasis, immune evasion, tumor angiogenesis, epithelial-mesenchymal
transition (EMT) and the Warburg effect.;
Molecule name : YY-201; YY 201;
Origin ID : C207266;
concept_is_in_subset
- has_target
