" /> Glycine Receptor Complex - CISMeF





Preferred Label : Glycine Receptor Complex;

NCIt synonyms : GLR; Strychnine-Sensitive GlyR; Strychnine-Sensitive Glycine Receptor;

NCIt related terms : GlyR; GLYCINE RECEPTOR;

NCIt definition : A family of ligand-gated pentameric ion channel complexes where the five subunits surround a central pore composed of 2 to 5 ligand-binding transmembrane alpha subunits associated with 0 to 3 beta subunits. Glycine receptors (GlyRs) are ionotropic receptors that regulate chloride transport upon binding to the amino acid neurotransmitter glycine. Other ligands include other small amino acids, such as alanine, proline, serine, sarcosine and taurine; while quercetin, caffeine and strychnine are some of the small molecule antagonists for GlyRs.;

Alternative definition : CDISC: The ligand-gated chloride ion channel that binds to and mediates the neurotransmission of glycine. Glycine receptors are composed of two main subunits, alpha and beta. It can be considered as an autoantigen and is commonly associated with the autoimmune neurological disorder stiff-person syndrome.;

NCIt note : There are 3 human glycine receptor (GlyR) alpha isoforms (GLRA1-3) and one beta isoform (GLRB). Each ion channel contains only one type of alpha isoform. GlyR composition is developmental stage- and tissue-specific.;

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07/05/2025


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