Preferred Label : MHC Class I Protein;
NCIt synonyms : Histocompatibility Antigen, Class I; Complex Class 1; Human Leukocyte Antigen; MHC Class I Molecule; Major Histocompatibility Complex Class 1; Class I MHC Protein; MHC Class-I Protein;
NCIt related terms : HLA CLASS I ANTIGENS;
NCIt definition : Found on virtually every cell, MHC (Major Histocompatibility, HLA) Class-I (Antigens)
Proteins consist of noncovalently bound polymorphic 44-kDa MHC membrane glycoprotein
and nonpolymorphic 12-kDa b2-microglobulin. The HLA antigens are encoded by closely
linked multiallelic genes of the HLA (MHC) complex, a region containing several genetic
loci (HLA-A, -B, -C, -DP, -DQ, -DR, -MB, -MT, and -Te).;
Alternative definition : CDISC: A group of human leukocyte antigens that are typically expressed as transmembrane
glycoproteins on the surface of all nucleated cells, and consist mainly of (but are
not limited to) HLA-A, HLA-B and HLA-C.;
Origin ID : C20706;
UMLS CUI : C0019629;
Automatic exact mappings (from CISMeF team)
- Biochemical function of gene products
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_expressed_in_tissue
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_plays_role_in_biological_process
- is_chemical_classification_of_gene_product
