MHC Class I Protein

Preferred Label : MHC Class I Protein;

NCIt synonyms : Histocompatibility Antigen, Class I; Complex Class 1; Human Leukocyte Antigen; MHC Class I Molecule; Major Histocompatibility Complex Class 1; Class I MHC Protein; MHC Class-I Protein;

NCIt definition : Found on virtually every cell, MHC (Major Histocompatibility, HLA) Class-I (Antigens) Proteins consist of noncovalently bound polymorphic 44-kDa MHC membrane glycoprotein and nonpolymorphic 12-kDa b2-microglobulin. The HLA antigens are encoded by closely linked multiallelic genes of the HLA (MHC) complex, a region containing several genetic loci (HLA-A, -B, -C, -DP, -DQ, -DR, -MB, -MT, and -Te).;

Details

Origin ID

C20706;

UMLS CUI

C0019629;

Automatic exact mappings (from CISMeF team)
- Class I major histocompatibility complex protein [FMA entity]
- HLA Ag [LOINC component]
- HLA antigens [MeSH concept]
- HLA antigens [MeSH Descriptor]
- HLA system [Blood Transfusion thesaurus concept]
- Human leukocyte antigen (substance) [SNOMED CT concept]
- Human leukocyte antigen A (substance) [SNOMED CT concept]
- Human leukocyte antigen present (finding) [Inactive SNOMED CT concept]
Biochemical function of gene products
- KIR Ligand [NCIt concept]
Currated CISMeF NLP mapping
- histocompatibility antigens class I [MeSH concept]
- histocompatibility antigens class i [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- histocompatibility antigens class I [MeSH concept]
- histocompatibility antigens class i [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Immunoprotein Gene [NCIt concept]
- MHC Class I Gene [NCIt concept]
gene_product_expressed_in_tissue
- CD8-Positive T-Lymphocyte [NCIt concept]
gene_product_has_chemical_classification
- HLA Complex [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Antigen Presentation [NCIt concept]
- Immune System Process [NCIt concept]
- Immunoregulation [NCIt concept]
is_chemical_classification_of_gene_product
- Hereditary Hemochromatosis Protein [NCIt concept]
- UL16-Binding Protein 1 [NCIt concept]
- UL16-Binding Protein 2 [NCIt concept]
- UL16-Binding Protein 3 [NCIt concept]
- UL16-Binding Protein 6 [NCIt concept]

Keyword's position in hierarchy(ies) :

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