Preferred Label : Anti-B7-H4 Antibody Drug Conjugate BG-C9074;
NCIt synonyms : ADC BG-C9074; Anti-B7-H4 ADC BG-C9074;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
the T-cell checkpoint ligand B7-H4 (V-set domain-containing T-cell activation inhibitor
1; VTCN1; B7x; B7S1) linked to an as of yet unknown cytotoxic agent, with potential
antineoplastic activity. Upon administration of anti-B7-H4 ADC BG-C9074, the anti-B7-H4
monoclonal antibody moiety targets and binds to B7-H4 expressed on tumor cells. Upon
binding and internalization, the cytotoxic agent exerts an as of yet unknown mechanism
of action (MoA) causing apoptosis in B7-H4-expressing tumor cells. B7-H4, a member
of the B7 family of immune modulators, is upregulated in a variety of tumor cell types
and tumor-associated macrophages (TAMs). It negatively regulates T-cell immune responses.;
Molecule name : BG-C9074; BG C9074;
Origin ID : C207043;
concept_is_in_subset
- has_target
