NCIt definition : Nuclear receptor coactivator genes encode a class of proteins that are recruited and
serve as bridging molecules between the transcription initiation complex and nuclear
receptors (NRs). Most of these coactivators interact with the AF-2 domain of NRs through
one or several LXXLL motifs called NR box. Members of NRs includes the 5 steroid receptors
and class II nuclear receptors. After binding to enhancer elements, transcription
factors require transcriptional coactivator proteins to mediate their stimulation
of transcription initiation. (NCI);
See also inter- (CISMeF)