Secretogranin-2

Preferred Label : Secretogranin-2;

NCIt synonyms : SCG2; Chromogranin C; EM66 Precursor; Secretogranin II Precursor; SgII; Secretoneurin Precursor; Secretogranin II; Secretogranin-II;

NCIt definition : Secretogranin-2 (617 aa, 71 kDa) is encoded by the human SCG2 gene. This protein is involved in chemotaxis, apoptosis and both proliferation and migration of endothelial cells.;

NCIt note : The protein is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. (LocusLink); Secretogranin-2 is a precursor that is cleaved to produce secretoneurin.;

Details

Origin ID

C20685;

UMLS CUI

C1569744;

Currated CISMeF NLP mapping
- secretogranin II [MeSH concept]
- secretogranin ii [MeSH Descriptor]
OMIM relation
- Secretogranin II [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- SCG2 protein, human [MeSH Supplementary Concept]
- SCG2 protein, human [MeSH concept]
- secretogranin II [MeSH concept]
- secretogranin ii [MeSH Descriptor]
gene_encodes_gene_product
- Chromogranin Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
- SCG2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Adrenal Medulla [NCIt concept]
- Anterior Lobe of the Pituitary Gland [NCIt concept]
- Secretory Granule [NCIt concept]
gene_product_has_biochemical_function
- Chromogranin [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_plays_role_in_biological_process
- Chemotactic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

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