Preferred Label : Zirconium Zr 89-DFO-emapalumab;
NCIt synonyms : Zr89-DFO-emapalumab; Zirconium Zr 89 DFO-emapalumab; [89Zr]-DFO-emapalumab;
NCIt definition : A radioimmunoconjugate comprised of emapalumab, a human monoclonal antibody directed
against the cytokine interferon-gamma (IFN-gamma; IFNg), linked, via the chelator
desferrioxamine (DFO), to the radioisotope zirconium Zr 89 (Zr89), with potential
use as an imaging agent upon positron emission tomography (PET). Upon administration
of Zr89-DFO-emapalumab, the emapalumab moiety specifically targets and binds to IFNg.
Upon binding, the radioisotope moiety is detected using PET, thereby allowing the
imaging of IFNg. This may help detect lesions and assess response to immunotherapeutic
agents. IFNg, a cell-signaling protein, plays a key role in the regulation and activation
of the immune system.;
NCI Metathesaurus CUI : CL1928968;
Origin ID : C206458;
concept_is_in_subset
- has_target
