Preferred Label : Anti-TNFR2 Monoclonal Antibody BI-1910;
NCIt synonyms : Anti-TNFR2 Agonistic Monoclonal Antibody BI-1910; TNFR2 Agonist Antibody BI-1910;
NCIt definition : An agonistic monoclonal antibody directed against tumor necrosis factor receptor 2
(TNFR2; tumor necrosis factor receptor superfamily member 1B; TNFRSF1B), with potential
antineoplastic activity. Upon administration, anti-TNFR2 monoclonal antibody BI-1910
targets and binds to TNFR2 expressed on the surface of CD4 T-cells, CD8 T-cells
and natural killer (NK) cells in the tumor microenvironment (TME), thereby activating
CD4 T-cells, CD8 T-cells and NK cells. This may enhance cytotoxic T-cell- and NK
cell-mediated immune responses against tumor cells. TNFR2, a member of the TNFR family
of co-stimulatory molecules, plays an important role in T-cell co-stimulation.;
Molecule name : BI-1910; BI 1910;
NCI Metathesaurus CUI : CL1928604;
Origin ID : C206260;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
