Preferred Label : MAT2A Inhibitor S-095035;
NCIt synonyms : Methionine Adenosyltransferase 2 Alpha Inhibitor S-095035;
NCIt definition : An orally bioavailable inhibitor of methionine adenosyltransferase II alpha (MAT2A),
with potential antineoplastic activity. Upon oral administration, MAT2A inhibitor
S-095035 targets, binds to and inhibits the activity of MAT2A, a metabolic enzyme
responsible for the production of S-adenosyl-L-methionine (SAM), a primary donor of
methyl groups in cellular transmethylation reactions that regulate gene expression,
cell growth, and differentiation. Inhibition of MAT2A may inhibit proliferation in
methylthioadenosine phosphorylase (MTAP)-deleted cancers that rely heavily on SAM
synthesis. MAT2A activity is essential in cancer cells deficient in MTAP, a critical
enzyme in the methionine salvage pathway, that is deleted in a variety of human cancers.;
Molecule name : S 095035; S-095035;
NCI Metathesaurus CUI : CL1928590;
Origin ID : C206258;
concept_is_in_subset
- has_target
