Preferred Label : IDO1 Inhibitor RiMO-401;
NCIt synonyms : IDO-1 Inhibitor RiMO-401;
NCIt definition : An inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1; IDO-1), with potential immunomodulating
and antineoplastic activities. Upon intra-tumoral administration, IDO1 inhibitor RiMO-401
specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation
of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By
inhibiting IDO1 and decreasing kynurenine in tumor cells, RiMO-401 restores and promotes
the proliferation and activation of various immune cells, including dendritic cells
(DCs), natural killer (NK) cells, and T-lymphocytes, and causes a reduction in tumor-associated
regulatory T-cells (Tregs). Re-activation of the immune system, which is suppressed
in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against the IDO1-expressing
tumor cells, thereby inhibiting the growth of IDO1-expressing tumor cells. IDO1, overexpressed
by multiple tumor cell types, plays an important role in immunosuppression. Tryptophan
depletion inhibits T-lymphocyte proliferation and activation, and subsequently suppresses
the immune system.;
Molecule name : RiMO 401; RiMO-401;
NCI Metathesaurus CUI : CL1928593;
Origin ID : C206255;
concept_is_in_subset
- has_target
