Preferred Label : Anti-ENPP3/Anti-CD3 Bispecific Antibody JNJ-87890387;
NCIt synonyms : Anti-ENPP3/Anti-CD3 T-cell Redirector JNJ-87890387; TCE JNJ-87890387; Anti-ENPP3/Anti-CD3 Bispecific ENPP3 T-cell Redirector JNJ-87890387; Anti-ENPP3/CD3 Bispecific Antibody JNJ-87890387; T-cell Engager JNJ-87890387; Anti-ENPP3/CD3 Bispecific ENPP3 T-cell Redirector JNJ-87890387; ENPP3 x CD3 Bispecific Antibody JNJ-87890387;
NCIt definition : A human bispecific antibody directed against both ectonucleotide pyrophosphatase/phosphodiesterase
family member 3 (ENPP3; NPP3; B10; PDNP3; CD203c; PD-IBETA) and the T-cell surface
antigen CD3, with potential immunostimulatory and antineoplastic activities. Upon
administration, anti-ENPP3/anti-CD3 bispecific antibody JNJ-87890387 targets and binds
to ENPP3 expressed on tumor cells and CD3 expressed on T-cells. The resulting cross-linkage
may trigger a potent cytotoxic T-lymphocyte (CTL) response against ENPP3-expressing
tumor cells. While normally expressed at low levels on tubules of the kidney cortex
and by some cells in gastrointestinal, adrenal, and endometrial tissues, the type
II transmembrane glycoprotein ENPP3 is overexpressed in various cancers including
most renal neoplasms and some liver cancers.;
Molecule name : JNJ 87890387; JNJ-87890387;
NCI Metathesaurus CUI : CL1928582;
Origin ID : C206251;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
