Inactive Tyrosine-Protein Kinase PEAK1

Preferred Label : Inactive Tyrosine-Protein Kinase PEAK1;

NCIt synonyms : Pseudopodium Enriched Atypical Kinase 1; PEAK1; Pseudopodium-Enriched Atypical Kinase 1; Tyrosine-Protein Kinase SgK269; Sugen Kinase 269;

NCIt definition : Inactive tyrosine-protein kinase PEAK1 (1746 aa, 193 kDa) is encoded by the human PEAK1 gene. This protein is involved in the modulation of focal adhesion dynamics.;

NCIt note : The catalytic activity of inactive tyrosine-protein kinase PEAK1 has been a subject of controversy. In vitro studies found weak tyrosine-protein kinase activity. However, the crystal structure indicates that the kinase-domain contains a closed nucleotide-binding cleft and a thermal-shift assay indicates that the protein is devoid of nucleotide binding activity. (UniProt);

Details

Origin ID

C206186;

OMIM relation
- Peak family member 1 [OMIM gene]
gene_encodes_gene_product
- Adaptor Signaling Protein Gene [NCIt concept]
- PEAK1 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoskeleton [NCIt concept]
- Cytosol [NCIt concept]
- Focal Adhesion [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Growth Process [NCIt concept]
- Cellular Migration Process [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Substrate Interaction [NCIt concept]

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