Preferred Label : MAGE-A4-specific T-cell Engager CDR404;
NCIt synonyms : TCE CDR404; MAGE-A4 M-gager CDR404; Anti-MAGE-A4/Anti-CD3 Bispecific Antibody CDR404; MAGE-A4-targeting T-cell Engager CDR404;
NCIt definition : A bispecific T-cell engaging antibody directed against the human leukocyte antigen
(HLA)-A2-restricted tumor-associated antigen (TAA) human melanoma-associated antigen
A4 (MAGE-A4) and the T-cell surface antigen CD3, with potential immunostimulating
and antineoplastic activities. Upon intravenous administration of the MAGE-A4-specific
T-cell engager (TCE) CDR404, the anti-MAGE-A4 moiety targets and binds to MAGE-A4
presented on HLA-A2 on tumor cells and the anti-CD3 moiety binds to CD3- expressing
cytotoxic T-lymphocytes (CTLs). This selectively cross-links tumor cells and T-lymphocytes
and results in a CTL-mediated death of MAGE-A4-expressing tumor cells. MAGE-A4 is
overexpressed by a variety of cancer cell types.;
Molecule name : CDR-404; CDR 404;
NCI Metathesaurus CUI : CL1928488;
Origin ID : C206172;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
