Preferred Label : SWI/SNF Family Complex;
NCIt synonyms : Mating Type Switching/Sucrose Nonfermenting Protein; SWI-SNF Family Complex;
NCIt definition : Involved in transcriptional activation of numerous genes, yeast SWI2/SNF2 contains
a highly conserved domain among helicases required for transcriptional activity. Mammalian
SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes implicated in regulation
of gene expression, cell cycle control, and oncogenesis. The SWI/SNF complex is thought
to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated
transcriptional repression. The complex contains an ATP-dependent nucleosome disruption
activity that can lead to enhanced binding of transcription factors. During mitosis,
the human protein is phosphorylated, excluded from condensed chromosomes, and the
protein level is strongly reduced. (from OMIM 600014 and NCI);
Origin ID : C20591;
UMLS CUI : C1335883;
Semantic type(s)
- has_gene_product_element
