Preferred Label : Anti-CLDN6/CD3 Bispecific Antibody XmAb541;
NCIt synonyms : CLDN6 x CD3 Bispecific Antibody XmAb541; Anti-CLDN6/CD3 XmAb 2 1 Bispecific Antibody XmAb541; Anti-CLDN6/CD3 T-cell Engaging Bispecific Antibody XmAb541; Anti-CD3/CLDN6 Bispecific Antibody XmAb541; Anti-CLDN6/Anti-CD3 Bispecific Antibody XmAb541;
NCIt definition : A bispecific antibody directed against both the tumor-associated antigen (TAA) Claudin
6 (CLDN6; CLDN-6) and the T-cell surface antigen CD3, with potential immunostimulating
and antineoplastic activities. Upon administration, anti-CLDN6/CD3 bispecific antibody
XmAb541 bivalently binds to CLDN6 expressed on tumor cells and monovalently binds
to CD3 expressed on T-cells. This activates and redirects cytotoxic T-lymphocytes
(CTLs) to CLDN6-expressing tumor cells, which leads to enhanced CTL-mediated killing
of CLDN6-expressing tumor cells. CLDN6, a tight-junction protein and embryonic antigen,
is expressed on a variety of tumor cells but is not expressed on normal, healthy adult
cells. The bivalent binding to CLDN6 and monovalent binding to CD3 by XmAb541 may
increase selective targeting of CLDN6-overexpressing tumor cells.;
Molecule name : XmAb-541; XmAb 541;
NCI Metathesaurus CUI : CL1928386;
Origin ID : C205772;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
