Preferred Label : STAT3 Inhibitor VVD-130850;
NCIt definition : An orally bioavailable small molecule inhibitor of signal transducer and activator
of transcription 3 (STAT3), with potential antineoplastic activity. Upon oral administration,
STAT3 inhibitor VVD-130850 targets and binds to an allosteric pocket of STAT3. This
prevents STAT3 binding to responsive gene promoters, STAT3-mediated signaling and
the expression of STAT3 target genes, thereby inhibiting the proliferation of STAT3-overexpressing
tumor cells. STAT3 regulates the transcription of genes involved in several cellular
functions. STAT3 is constitutively activated in a variety of human cancers and plays
a key role in neoplastic transformation, uncontrolled tumor cell proliferation, resistance
to apoptosis, metastasis, immune evasion, tumor angiogenesis, epithelial-mesenchymal
transition (EMT) and the Warburg effect.;
Molecule name : VVD-130850; VVD 130850;
NCI Metathesaurus CUI : CL1928297;
Origin ID : C205626;
concept_is_in_subset
- has_target
