Preferred Label : PD-1 Targeted IL-2 Mutein Fusion Protein KY-0118;
NCIt synonyms : PD-1-targeting IL-2 Mutein Fusion Protein KY-0118;
NCIt definition : A fusion protein comprised of a human negative immunoregulatory checkpoint receptor
programmed cell death protein 1 (PD-1; PDCD1; CD279)-targeting moiety linked to an
interleukin-2 (IL-2) mutein, with potential immunostimulating and antineoplastic activities.
Upon administration of PD-1-targeted IL-2 mutein fusion protein KY-0118, the PD-1
targeting moiety targets and binds to PD-1 expressed on tumor-infiltrating lymphocytes
(TILs) and inhibits PD-1-mediated downregulation of T-cell activation and proliferation.
The IL-2 mutein moiety activates IL-2 cytokine signaling. This stimulates a local
immune response and activates natural killer (NK) cells and cytotoxic T-cells. This
may enhance the activity of neoantigen specific T-cells and potentiates T-cell-mediated
immune responses against tumor cells. PD-1, a transmembrane protein in the immunoglobulin
superfamily (IgSF) expressed on T-cells, functions as an immune checkpoint that negatively
regulates T-cell activation and effector function when activated by its ligands, programmed
cell death-1 ligand 1 (PD-L1; B7-H1; CD274) and 2 (PD-L2); it plays an important role
in tumor evasion from host immunity.;
Molecule name : KY 0118; KY-0118;
NCI Metathesaurus CUI : CL1927631;
Origin ID : C205443;
concept_is_in_subset
- has_target
