Preferred Label : Anti-LILRB4/MMAE ADC SG2918;
NCIt synonyms : Anti-ILT3/MMAE ADC SG2918; Anti-LILRB4 Antibody-drug Conjugate SG2918; ADC SG2918;
NCIt definition : An antibody-drug conjugate (ADC) consisting of a monoclonal antibody directed against
leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4; ILT3; ILT-3)
conjugated to monomethyl auristatin E (MMAE), an auristatin derivative and potent
microtubule disrupting agent, with potential antineoplastic activity. Upon administration
of anti-LILRB4/MMAE ADC SG2918, the monoclonal antibody moiety targets and binds to
LILRB4. After internalization of the agent, the MMAE moiety is released, binds to
tubulin and inhibits its polymerization, which results in G2/M phase cell cycle arrest
and apoptosis. This inhibits the proliferation of LILRB4-expressing tumor cells and
may re-activate the immune system. LILRB4, an inhibitory immune receptor highly expressed
on tumor-associated myeloid cells, primarily tolerogenic dendritic cells (DCs), myeloid-derived
suppressor cells (MDSCs) and M2 macrophages, functions as an immune checkpoint that
negatively regulates DC- and T-cell activation. It is upregulated in several tumor
types and plays an important role in tumor infiltration, immunosuppression and immune
tolerance.;
Molecule name : SG-2918; SG 2918;
NCI Metathesaurus CUI : CL1927039;
Origin ID : C204805;
UMLS CUI : C5908062;
Semantic type(s)
- concept_is_in_subset
- has_target
