Preferred Label : Anti-HER3/Topoisomerase I Inhibitor Antibody-drug Conjugate IBI133;
NCIt synonyms : Anti-HER3/TopoI Inhibitor ADC IBI133; Anti-HER3/TopIi Antibody-drug Conjugate IBI133; Anti-HER3 Antibody-drug Conjugate IBI133; Anti-HER3 ADC IBI133;
NCIt definition : An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against
human epidermal growth factor receptor 3 (HER3; ErbB3) conjugated to a topoisomerase
I (TopoI) inhibitor-based payload, with potential antineoplastic activity. Upon administration
of anti-HER3/TopoI inhibitor ADC IBI133, the anti-HER3 antibody moiety targets and
binds to HER3 expressed on tumor cells. Upon cellular uptake, the TopoI inhibitor
inhibits DNA topoI activity, thereby inhibiting DNA replication which results in cell
cycle arrest and tumor cell apoptosis. This inhibits the proliferation of HER3-expressing
tumor cells. HER3, a member of the epidermal growth factor receptor (EGFR) family
of receptor tyrosine kinases, is frequently overexpressed in tumors.;
Molecule name : IBI 133; IBI-133;
NCI Metathesaurus CUI : CL1927040;
Origin ID : C204804;
UMLS CUI : C5908061;
Semantic type(s)
- concept_is_in_subset
- has_target
