Metalloreductase STEAP2

Preferred Label : Metalloreductase STEAP2;

NCIt synonyms : STAMP1; PUMPCn; SixTransMembrane Protein of Prostate 1; Prostate Cancer Associated Protein 1; EC 1.16.1.-; Prostate Cancer-Associated Protein 1; Protein Up-Regulated In Metastatic Prostate Cancer; STEAP2 Metalloreductase; Six-Transmembrane Epithelial Antigen of Prostate 2; STEAP2; Six-Transmembrane Epithelial Antigen of the Prostate 2;

NCIt definition : Metalloreductase STEAP2 (490 aa, 56 kDa) is encoded by the human STEAP2 gene. This protein is involved in reversible NADPH-dependent conversion of chelated ferric ions to chelated ferrous ions and may also convert cupric ions to cuprous ions.;

Details

Origin ID

C204513;

UMLS CUI

C1172029;

OMIM relation
- Steap2 metalloreductase [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- STEAP2 protein, human [MeSH Supplementary Concept]
- STEAP2 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
- STEAP2 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Early Endosome [NCIt concept]
- Membrane of the Endosome [NCIt concept]
- Plasma Membrane [NCIt concept]
- Trans-Golgi Network [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Copper Chelation [NCIt concept]
- Ion Transport Process [NCIt concept]
- Iron Chelation [NCIt concept]
- Metabolism, Minerals/Electrolytes [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
is_target
- Autologous dnTGF-BRII-armored Anti-STEAP2 CAR T-cells AZD0754 [NCIt concept]

Keyword's position in hierarchy(ies) :

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