Preferred Label : EGFRt/19-28z/IL-12 CAR T-lymphocytes;
NCIt synonyms : EGFRt/19-28z/IL-12 CAR T Cells; Anti-CD19 CAR-CD28-CD3zeta-IL-12-EGFRt-expressing T-lymphocytes; EGFRt/19-28z/IL-12 CAR-T Cells; EGFRt/19-28z/IL-12 CAR T-cells;
NCIt definition : A preparation of T-lymphocytes that have been genetically modified to express a chimeric
antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment)
fused to the extracellular, transmembrane and intracellular signaling domains of the
T-cell co-stimulatory receptor CD28 and the cytoplasmic signaling domain of the zeta
chain of the TCR/CD3 complex (CD3-zeta) (19-28z), a truncated form of the human epidermal
growth factor receptor (EGFRt), and the human pro-inflammatory cytokine interleukin-12
(IL-12), with potential immunostimulating and antineoplastic activities. Upon administration,
EGFRt/19-28z/IL-12 CAR T-lymphocytes are directed to and induce selective toxicity
in CD19-expressing tumor cells. In addition, the administered T-cells secrete IL-12
which induces the secretion of interferon-gamma (IFN-g), promotes the activation of
natural killer cells (NKs), and induces cytotoxic T-lymphocyte (CTL) responses against
tumor cells, which may result in immune-mediated tumor cell death and inhibition of
tumor cell proliferation. CD19 antigen is a B-cell specific cell surface antigen expressed
in all B-cell lineage malignancies. The CD28 co-stimulatory molecule signaling domain
enhances activation and signaling after recognition of CD19. The inclusion of the
CD28 signaling domain may increase proliferation of the T-cells and their antitumor
activity compared with the inclusion of the CD3-zeta chain alone. Devoid of both ligand
binding domains and tyrosine kinase activity, EGFRt facilitates both the in vivo detection
of the administered T-cells and the elimination of the administered T-cells through
a cetuximab-induced antibody dependent cellular cytotoxicity (ADCC) response.;
NCI Metathesaurus CUI : CL1926581;
Origin ID : C204501;
UMLS CUI : C5909789;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
