Peroxisomal Targeting Signal 1 Receptor

Preferred Label : Peroxisomal Targeting Signal 1 Receptor;

NCIt synonyms : Peroxisomal Targeting Signal Receptor 1; PTS1R; PEX5; Peroxin-5; Peroxisomal Targeting Signal Import Receptor; Peroxisome Receptor 1; PTS1-BP; PTS1 Receptor; Peroxisome Biogenesis Factor 5; Peroxisomal Biogenesis Factor 5; Peroxin 5; Peroxisomal C-Terminal Targeting Signal Import Receptor;

NCIt definition : Peroxisomal targeting signal 1 receptor (639 aa, 71 kDa) is encoded by the human PEX5 gene. This protein plays a role in recognition of peroxisome targeting signals (PTS) and the transport of proteins into the peroxisome matrix.;

NCIt note : Peroxisomal targeting signal 1 receptor specifically binds to and promotes peroxisomal translocation of proteins containing a peroxisome targeting signal type 1 (PTS1) but it can also mediate the translocation of cargo containing PTS2 sequences via interactions with peroxisomal targeting signal 2 receptor (PEX7). (UniProt);

NCI Metathesaurus CUI : CL788671;

Details

Origin ID

C204454;

UMLS CUI

C4546676;

OMIM relation
- Peroxisome biogenesis factor 5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- PEX5 protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- PEX5 Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- Transport Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cellular Membrane [NCIt concept]
- Membrane of the Golgi Apparatus [NCIt concept]
- Membrane of the Peroxisome [NCIt concept]
- Mitochondrial Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Amphipathic Alpha Helix [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Tetratricopeptide Repeat [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Peroxisome Biogenesis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Subcellular Protein Targeting [NCIt concept]
- Transport Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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